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Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

While the transition metal copper (Cu) is an essential nutrient that is conventionally viewed as a static cofactor within enzyme active sites, a nontraditional role for Cu as a modulator of kinase signaling is emerging. We discovered that Cu is required for the activity of the autophagic kinases ULK...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Cell Biol
Prif Awduron: Tsang, Tiffany, Posimo, Jessica M., Gudiel, Andrea A., Cicchini, Michelle, Feldser, David M., Brady, Donita C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610258/
https://ncbi.nlm.nih.gov/pubmed/32203415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0481-4
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