Context dependent effects of amplified MAPK signaling during lung adenocarcinoma initiation and progression

Expression of oncogenic Kras(G12D) initiates lung adenomas in a MAPK signal-dependent manner from only a subset of cell types in the adult mouse lung. Amplification of MAPK signaling is associated with progression to malignant adenocarcinomas, but whether this is a cause or consequence of disease pr...

Full description

Saved in:
Bibliographic Details
Published in:Cell Rep
Main Authors: Cicchini, Michelle, Buza, Elizabeth L., Sagal, Kyra M., Gudiel, A. Andrea, Durham, Amy C., Feldser, David M.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5405440/
https://ncbi.nlm.nih.gov/pubmed/28228261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.069
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items