Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction

Macrophages (Mφs) produce factors that participate in cardiac repair and remodeling after myocardial infarction (MI); however, how these factors crosstalk with other cell types mediating repair is not fully understood. Here we demonstrated that cardiac Mφs increased the expression of Mmp14 (MT1-MMP)...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Alonso-Herranz, Laura, Sahún-Español, Álvaro, Paredes, Ana, Gonzalo, Pilar, Gkontra, Polyxeni, Núñez, Vanessa, Clemente, Cristina, Cedenilla, Marta, Villalba-Orero, María, Inserte, Javier, García-Dorado, David, Arroyo, Alicia G, Ricote, Mercedes
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2020
Sujets:
Immunology and Inflammation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7609061/
https://ncbi.nlm.nih.gov/pubmed/33063665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57920
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