Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice

Staphylococcus aureus infection of bone is challenging to treat because it colonizes the osteocyte lacuno-canalicular network (OLCN) of cortical bone. To elucidate factors involved in OLCN invasion and identify novel drug targets, we completed a hypothesis-driven screen of 24 S. aureus transposon in...

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Détails bibliographiques
Publié dans:PLoS Pathog
Auteurs principaux: Masters, Elysia A., de Mesy Bentley, Karen L., Gill, Ann Lindley, Hao, Stephanie P., Galloway, Chad A., Salminen, Alec T., Guy, Diamond R., McGrath, James L., Awad, Hani A., Gill, Steven R., Schwarz, Edward M.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608983/
https://ncbi.nlm.nih.gov/pubmed/33091079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008988
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