Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice

Staphylococcus aureus infection of bone is challenging to treat because it colonizes the osteocyte lacuno-canalicular network (OLCN) of cortical bone. To elucidate factors involved in OLCN invasion and identify novel drug targets, we completed a hypothesis-driven screen of 24 S. aureus transposon in...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Masters, Elysia A., de Mesy Bentley, Karen L., Gill, Ann Lindley, Hao, Stephanie P., Galloway, Chad A., Salminen, Alec T., Guy, Diamond R., McGrath, James L., Awad, Hani A., Gill, Steven R., Schwarz, Edward M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608983/
https://ncbi.nlm.nih.gov/pubmed/33091079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008988
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