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Hnf4a Is Required for the Development of Cdh6-Expressing Progenitors into Proximal Tubules in the Mouse Kidney

BACKGROUND: Hepatocyte NF 4α (Hnf4a) is a major regulator of renal proximal tubule (PT) development. In humans, a mutation in HNF4A impairs PT functions and is associated with Fanconi renotubular syndrome (FRTS). In mice, mosaic deletion of Hnf4a in the developing kidney reduces the population of PT...

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Pubblicato in:J Am Soc Nephrol
Autori principali: Marable, Sierra S., Chung, Eunah, Park, Joo-Seop
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608976/
https://ncbi.nlm.nih.gov/pubmed/32764140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020020184
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