Cross-talk between CDK4/6 and SMYD2 regulates gene transcription, tubulin methylation, and ciliogenesis

Dysregulation of cyclin-dependent kinases 4 and 6 (CDK4/6) by unknown mechanisms is highly prevalent in human disease. In this study, we identify direct cross-talk between CDK4/6 and the epigenome via its previously unidentified substrate, SMYD2, a histone/lysine methyltransferase. CDK4/6 positively...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Li, Linda Xiaoyan, Zhou, Julie Xia, Wang, Xiaodong, Zhang, Hongbing, Harris, Peter C., Calvet, James P., Li, Xiaogang
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608814/
https://ncbi.nlm.nih.gov/pubmed/33127671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb3154
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