Leukemia-on-a-chip: Dissecting the chemoresistance mechanisms in B cell acute lymphoblastic leukemia bone marrow niche

B cell acute lymphoblastic leukemia (B-ALL) blasts hijack the bone marrow (BM) microenvironment to form chemoprotective leukemic BM “niches,” facilitating chemoresistance and, ultimately, disease relapse. However, the ability to dissect these evolving, heterogeneous interactions among distinct B-ALL...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Ma, Chao, Witkowski, Matthew T., Harris, Jacob, Dolgalev, Igor, Sreeram, Sheetal, Qian, Weiyi, Tong, Jie, Chen, Xin, Aifantis, Iannis, Chen, Weiqiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608809/
https://ncbi.nlm.nih.gov/pubmed/33127669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba5536
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