Extensive Remodeling of the Immune Microenvironment in B-cell Acute Lymphoblastic Leukemia

A subset of B-cell acute lymphoblastic leukemia (B-ALL) patients will relapse and succumb to therapy-resistant disease. The bone marrow microenvironment may support B-ALL progression and treatment evasion. Utilizing single-cell approaches, we demonstrate B-ALL bone marrow immune microenvironment re-...

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Vydáno v:Cancer Cell
Hlavní autoři: Witkowski, Matthew T., Dolgalev, Igor, Evensen, Nikki A., Ma, Chao, Chambers, Tiffany, Roberts, Kathryn G., Sreeram, Sheetal, Dai, Yuling, Tikhonova, Anastasia N., Lasry, Audrey, Qu, Chunxu, Pei, Deqing, Cheng, Cheng, Robbins, Gabriel A., Pierro, Joanna, Selvaraj, Shanmugapriya, Mezzano, Valeria, Daves, Maria, Lupo, Philip J., Scheurer, Michael E., Loomis, Cynthia A., Mullighan, Charles G., Chen, Weiqiang, Rabin, Karen R., Tsirigos, Aristotelis, Carroll, William L., Aifantis, Iannis
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341535/
https://ncbi.nlm.nih.gov/pubmed/32470390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.04.015
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