Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy

Malignant cells may evade death from cytotoxic agents if they are in a dormant state. The host microenvironment plays important roles in cancer progression, but how niches might control cancer cell dormancy is little understood. Here we show that osteopontin (OPN), an extracellular matrix molecule s...

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Bibliografiske detaljer
Main Authors: Boyerinas, Benjamin, Zafrir, Maya, Yesilkanal, Ali E., Price, Trevor T., Hyjek, Elizabeth M., Sipkins, Dorothy A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2013
Fag:
Plenary Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682335/
https://ncbi.nlm.nih.gov/pubmed/23589674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-475483
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