Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription

CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few additional CDK7 substrates are known. Here, using the covalent inhibitor SY-351 and quantitative phosphoproteomics, we identified CDK7 kinas...

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Publicado en:Genes Dev
Autores principales: Rimel, Jenna K., Poss, Zachary C., Erickson, Benjamin, Maas, Zachary L., Ebmeier, Christopher C., Johnson, Jared L., Decker, Tim-Michael, Yaron, Tomer M., Bradley, Michael J., Hamman, Kristin B., Hu, Shanhu, Malojcic, Goran, Marineau, Jason J., White, Peter W., Brault, Martine, Tao, Limei, DeRoy, Patrick, Clavette, Christian, Nayak, Shraddha, Damon, Leah J., Kaltheuner, Ines H., Bunch, Heeyoun, Cantley, Lewis C., Geyer, Matthias, Iwasa, Janet, Dowell, Robin D., Bentley, David L., Old, William M., Taatjes, Dylan J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608751/
https://ncbi.nlm.nih.gov/pubmed/33060135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.341545.120
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