Human TFIIH kinase CDK7 regulates transcription-associated chromatin modifications

CDK7 phosphorylates the RNA polymerase II (pol II) CTD and activates the P-TEFb-associated kinase, CDK9, but its regulatory roles remain obscure. Here, using human CDK7 analog-sensitive (CDK7as) cells, we observed reduced capping enzyme recruitment, increased pol II promoter-proximal pausing, and de...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cell Rep
मुख्य लेखकों: Ebmeier, Christopher C., Erickson, Benjamin, Allen, Benjamin L., Allen, Mary A., Kim, Hyunmin, Fong, Nova, Jacobsen, Jeremy R., Liang, Kaiwei, Shilatifard, Ali, Dowell, Robin D., Old, William M., Bentley, David L., Taatjes, Dylan J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2017
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564226/
https://ncbi.nlm.nih.gov/pubmed/28768201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.021
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