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Human TFIIH kinase CDK7 regulates transcription-associated chromatin modifications
CDK7 phosphorylates the RNA polymerase II (pol II) CTD and activates the P-TEFb-associated kinase, CDK9, but its regulatory roles remain obscure. Here, using human CDK7 analog-sensitive (CDK7as) cells, we observed reduced capping enzyme recruitment, increased pol II promoter-proximal pausing, and de...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5564226/ https://ncbi.nlm.nih.gov/pubmed/28768201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.021 |
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