Human TFIIH kinase CDK7 regulates transcription-associated chromatin modifications

CDK7 phosphorylates the RNA polymerase II (pol II) CTD and activates the P-TEFb-associated kinase, CDK9, but its regulatory roles remain obscure. Here, using human CDK7 analog-sensitive (CDK7as) cells, we observed reduced capping enzyme recruitment, increased pol II promoter-proximal pausing, and de...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Ebmeier, Christopher C., Erickson, Benjamin, Allen, Benjamin L., Allen, Mary A., Kim, Hyunmin, Fong, Nova, Jacobsen, Jeremy R., Liang, Kaiwei, Shilatifard, Ali, Dowell, Robin D., Old, William M., Bentley, David L., Taatjes, Dylan J.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564226/
https://ncbi.nlm.nih.gov/pubmed/28768201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.021
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