EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism

EBF1 and PAX5 mutations are associated with the development of B progenitor acute lymphoblastic leukemia (B-ALL) in humans. To understand the molecular networks driving leukemia in the Ebf1(+/−)Pax5(+/−) (dHet) mouse model for B-ALL, we interrogated the transcriptional profiles and chromatin status...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Ramamoorthy, Senthilkumar, Kometani, Kohei, Herman, Josip S., Bayer, Marc, Boller, Sören, Edwards-Hicks, Joy, Ramachandran, Haribaskar, Li, Rui, Klein-Geltink, Ramon, Pearce, Erika L., Grün, Dominic, Grosschedl, Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608749/
https://ncbi.nlm.nih.gov/pubmed/33004416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.340216.120
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