A small UTX stabilization domain of Trr is conserved within mammalian MLL3-4/COMPASS and is sufficient to rescue loss of viability in null animals

Catalytic-inactivating mutations within the Drosophila enhancer H3K4 mono-methyltransferase Trr and its mammalian homologs, MLL3/4, cause only minor changes in gene expression compared with whole-gene deletions for these COMPASS members. To identify essential histone methyltransferase-independent fu...

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Опубликовано в: :Genes Dev
Главные авторы: Rickels, Ryan, Wang, Lu, Iwanaszko, Marta, Ozark, Patrick A., Morgan, Marc A., Piunti, Andrea, Khalatyan, Natalia, Soliman, Shimaa H.A., Rendleman, Emily J., Savas, Jeffrey N., Smith, Edwin R., Shilatifard, Ali
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2020
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608747/
https://ncbi.nlm.nih.gov/pubmed/33033055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.339762.120
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