p53 directly represses human LINE1 transposons

p53 is a potent tumor suppressor and commonly mutated in human cancers. Recently, we demonstrated that p53 genes act to restrict retrotransposons in germline tissues of flies and fish but whether this activity is conserved in somatic human cells is not known. Here we show that p53 constitutively res...

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Bibliografiska uppgifter
I publikationen:Genes Dev
Huvudupphovsmän: Tiwari, Bhavana, Jones, Amanda E., Caillet, Candace J., Das, Simanti, Royer, Stephanie K., Abrams, John M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2020
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608743/
https://ncbi.nlm.nih.gov/pubmed/33060137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.343186.120
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