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Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas
The p53 pathway is critical for tumor suppression, as the majority of human cancer has a faulty p53. Here, we identified RNPC1, a p53 target and a RNA-binding protein, as a critical regulator of p53 translation. We showed that ectopic expression of RNPC1 inhibited, whereas knockdown of RNPC1 increas...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3143942/ https://ncbi.nlm.nih.gov/pubmed/21764855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2069311 |
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