Inherited myeloproliferative neoplasm risk impacts hematopoietic stem cells

Myeloproliferative neoplasms (MPNs) are blood cancers characterized by excessive production of mature myeloid cells, which result from the acquisition of somatic driver mutations in hematopoietic stem cells (HSCs). Epidemiologic studies indicate a substantial disease heritability that is among the h...

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Publicat a:Nature
Autors principals: Bao, Erik L., Nandakumar, Satish K., Liao, Xiaotian, Bick, Alexander G., Karjalainen, Juha, Tabaka, Marcin, Gan, Olga I., Havulinna, Aki, Kiiskinen, Tuomo, Lareau, Caleb A., de Lapuente Portilla, Aitzkoa Lopez, Li, Bo, Emdin, Connor, Codd, Veryan, Nelson, Christopher P., Walker, Christopher J., Churchhouse, Claire, de la Chapelle, Albert, Klein, Daryl E., Nilsson, Björn, Wilson, Peter W.F., Cho, Kelly, Pyarajan, Saiju, Gaziano, J. Michael, Samani, Nilesh J., Regev, Aviv, Palotie, Aarno, Neale, Benjamin M., Dick, John E., Natarajan, Pradeep, O’Donnell, Christopher J., Daly, Mark J., Milyavsky, Michael, Kathiresan, Sekar, Sankaran, Vijay G.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606745/
https://ncbi.nlm.nih.gov/pubmed/33057200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2786-7
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