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Modulating disease-relevant tau oligomeric strains by small molecules

The pathological aggregation of tau plays an important role in Alzheimer's disease and many other related neurodegenerative diseases, collectively referred to as tauopathies. Recent evidence has demonstrated that tau oligomers, small and soluble prefibrillar aggregates, are highly toxic due to...

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Foilsithe in:J Biol Chem
Main Authors: Lo Cascio, Filippa, Garcia, Stephanie, Montalbano, Mauro, Puangmalai, Nicha, McAllen, Salome, Pace, Andrea, Palumbo Piccionello, Antonio, Kayed, Rakez
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606668/
https://ncbi.nlm.nih.gov/pubmed/32737202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014630
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