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Next generation miRNA inhibition using short anti-seed PNAs encapsulated in PLGA nanoparticles

Selective inhibition of microRNAs (miRNAs) offers a new avenue for cancer therapeutics. While most of the current anti-miRNA (antimiR) reagents target full length miRNAs, here we investigate novel nanoparticle-delivered short PNA probes containing cationic domains targeting the seed region of the mi...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Malik, Shipra, Lim, Jihoon, Slack, Frank J, Braddock, Demetrios T, Bahal, Raman
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606596/
https://ncbi.nlm.nih.gov/pubmed/32835710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.08.026
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