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Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles

Encapsulation of therapeutic molecules within polymer particles is a well-established method for achieving controlled release, yet challenges such as low loading, poor encapsulation efficiency, and loss of protein activity limit clinical translation. Despite this, the paradigm for the use of polymer...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Pakulska, Malgosia M., Elliott Donaghue, Irja, Obermeyer, Jaclyn M., Tuladhar, Anup, McLaughlin, Christopher K., Shendruk, Tyler N., Shoichet, Molly S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928928/
https://ncbi.nlm.nih.gov/pubmed/27386554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600519
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