Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles

Encapsulation of therapeutic molecules within polymer particles is a well-established method for achieving controlled release, yet challenges such as low loading, poor encapsulation efficiency, and loss of protein activity limit clinical translation. Despite this, the paradigm for the use of polymer...

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Bibliografische gegevens
Gepubliceerd in:Sci Adv
Hoofdauteurs: Pakulska, Malgosia M., Elliott Donaghue, Irja, Obermeyer, Jaclyn M., Tuladhar, Anup, McLaughlin, Christopher K., Shendruk, Tyler N., Shoichet, Molly S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Association for the Advancement of Science 2016
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928928/
https://ncbi.nlm.nih.gov/pubmed/27386554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1600519
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