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Copanlisib promotes growth inhibition and apoptosis by modulating the AKT/FoxO3a/PUMA axis in colorectal cancer

Colorectal cancer (CRC) is the type of cancer with the third highest incidence and is associated with high mortality and low 5-year survival rates. We observed that copanlisib, an inhibitor of PI3K (pan-class I phosphoinositide 3-kinase) that preferentially inhibits PI3Kδ and PI3Kα, impedes the grow...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Yan, Ji, Yang, Shida, Tian, Hong, Zhang, Yang, Zhao, Hongmei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606528/
https://ncbi.nlm.nih.gov/pubmed/33139695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03154-w
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