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Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency
Mutations in the molecular co-chaperone Bcl2-associated athanogene 3 (BAG3) are found to cause dilated cardiomyopathy (DCM), resulting in systolic dysfunction and heart failure, as well as myofibrillar myopathy (MFM), which is characterized by protein aggregation and myofibrillar disintegration in s...
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| Publicado no: | PLoS Genet |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7605898/ https://ncbi.nlm.nih.gov/pubmed/33137814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009088 |
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