ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease

Activation of the RIG-I-like receptors, RIG-I and MDA5, establishes an antiviral state by upregulating interferon (IFN)-stimulated genes (ISGs). Among these is ISG15 whose mechanistic roles in innate immunity still remain enigmatic. Here we report that ISGylation is essential for antiviral IFN respo...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Liu, GuanQun, Lee, Jung-Hyun, Parker, Zachary M., Acharya, Dhiraj, Chiang, Jessica J., van Gent, Michiel, Riedl, William, Davis-Gardner, Meredith E., Wies, Effi, Chiang, Cindy, Gack, Michaela U.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605552/
https://ncbi.nlm.nih.gov/pubmed/33140045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.26.356048
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