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Reduced penetrance of pathogenic ACMG variants in a deeply phenotyped cohort study and evaluation of ClinVar classification over time

PURPOSE: We studied the penetrance of pathogenically classified variants in an elderly Dutch population from the Rotterdam Study, for which deep phenotyping is available. We screened the 59 actionable genes for which reporting of known pathogenic variants was recommended by the American College of M...

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Bibliographische Detailangaben
Veröffentlicht in:Genet Med
Hauptverfasser: van Rooij, Jeroen, Arp, Pascal, Broer, Linda, Verlouw, Joost, van Rooij, Frank, Kraaij, Robert, Uitterlinden, André, Verkerk, Annemieke J. M. H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group US 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605437/
https://ncbi.nlm.nih.gov/pubmed/32665702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-020-0900-8
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