Pooled analysis of radiation hybrids identifies loci for growth and drug action in mammalian cells

Genetic screens in mammalian cells commonly focus on loss-of-function approaches. To evaluate the phenotypic consequences of extra gene copies, we used bulk segregant analysis (BSA) of radiation hybrid (RH) cells. We constructed six pools of RH cells, each consisting of ∼2500 independent clones, and...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genome Res
Egile Nagusiak: Khan, Arshad H., Lin, Andy, Wang, Richard T., Bloom, Joshua S., Lange, Kenneth, Smith, Desmond J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2020
Gaiak:
Method
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605260/
https://ncbi.nlm.nih.gov/pubmed/32878976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.262204.120
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