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Pooled analysis of radiation hybrids identifies loci for growth and drug action in mammalian cells
Genetic screens in mammalian cells commonly focus on loss-of-function approaches. To evaluate the phenotypic consequences of extra gene copies, we used bulk segregant analysis (BSA) of radiation hybrid (RH) cells. We constructed six pools of RH cells, each consisting of ∼2500 independent clones, and...
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| Publicado no: | Genome Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7605260/ https://ncbi.nlm.nih.gov/pubmed/32878976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.262204.120 |
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