A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE

Nicotinic acetylcholine receptors (nAChRs) are best known to function as ligand-gated ion channels in the nervous system. However, recent evidence suggests that nicotine modulates inflammation by desensitizing non-neuronal nAChRs, rather than by inducing channel opening. Silent agonists are molecule...

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Bibliographische Detailangaben
Veröffentlicht in:Brain Behav Immun
Hauptverfasser: Godin, Jean-Rémi, Roy, Patrick, Quadri, Marta, Bagdas, Deniz, Toma, Wisam, Narendrula-Kotha, Ramya, Kishta, Osama A., Damaj, M. Imad, Horenstein, Nicole A., Papke, Roger L., Simard, Alain R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604877/
https://ncbi.nlm.nih.gov/pubmed/31874200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2019.12.014
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