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Structural basis for CDK7 activation by MAT1 and Cyclin H

Cyclin-dependent kinase 7 (CDK7), Cyclin H, and the RING-finger protein MAT1 form the heterotrimeric CDK-activating kinase (CAK) complex which is vital for transcription and cell-cycle control. When associated with the general transcription factor II H (TFIIH) it activates RNA polymerase II by hyper...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Peissert, Stefan, Schlosser, Andreas, Kendel, Rafaela, Kuper, Jochen, Kisker, Caroline
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604442/
https://ncbi.nlm.nih.gov/pubmed/33055219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010885117
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