Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases

Remdesivir is a broad-spectrum antiviral nucleotide prodrug that has been clinically evaluated in Ebola virus patients and recently received emergency use authorization (EUA) for treatment of COVID-19. With approvals from the Federal Select Agent Program and the Centers for Disease Control and Preve...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lo, Michael K., Albariño, César G., Perry, Jason K., Chang, Silvia, Tchesnokov, Egor P., Guerrero, Lisa, Chakrabarti, Ayan, Shrivastava-Ranjan, Punya, Chatterjee, Payel, McMullan, Laura K., Martin, Ross, Jordan, Robert, Götte, Matthias, Montgomery, Joel M., Nichol, Stuart T., Flint, Mike, Porter, Danielle, Spiropoulou, Christina F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604432/
https://ncbi.nlm.nih.gov/pubmed/33028676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012294117
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