25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation

Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC). 25HC is involved in regulating...

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Publicado en:mBio
Autores principales: Shrivastava-Ranjan, Punya, Bergeron, Éric, Chakrabarti, Ayan K., Albariño, César G., Flint, Mike, Nichol, Stuart T., Spiropoulou, Christina F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5181775/
https://ncbi.nlm.nih.gov/pubmed/27999160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01808-16
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