Efficient Rescue of Recombinant Lassa Virus Reveals the Influence of S Segment Noncoding Regions on Virus Replication and Virulence

Lassa virus (LASV), is a significant cause of severe, often fatal, hemorrhagic fever in humans throughout western Africa, with an estimated 100,000 infections each year. No vaccines are commercially available. We report the development of an efficient reverse genetics system to rescue recombinant LA...

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Detalhes bibliográficos
Main Authors: Albariño, César G., Bird, Brian H., Chakrabarti, Ayan K., Dodd, Kimberly A., Erickson, Bobbie Rae, Nichol, Stuart T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126145/
https://ncbi.nlm.nih.gov/pubmed/21307206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02556-10
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