Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform

Limited drug loading capacity (LC), mostly below 5% w/w, is a significant drawback of nanoparticulate drug delivery systems (DDS). Squalenoylation technology, which employs bioconjugation of squalenyl moiety and drug, allows self-assemble of nanoparticles (NPs) in aqueous media with significantly hi...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Ho, Duy-Khiet, Christmann, Rebekka, Murgia, Xabier, De Rossi, Chiara, Frisch, Sarah, Koch, Marcus, Schaefer, Ulrich F., Loretz, Brigitta, Desmaele, Didier, Couvreur, Patrick, Lehr, Claus-Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604382/
https://ncbi.nlm.nih.gov/pubmed/33195079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.584242
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