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α-Secretase nonsense mutation (ADAM10 Tyr167*) in familial Alzheimer’s disease
BACKGROUND: The disintegrin metalloproteinase 10 (ADAM10) is the main α-secretase acting in the non-amyloidogenic processing of APP. Some ADAM10 gene variants have been associated with higher susceptibility to develop late-onset AD, though clear clinical-genetic correlates remain elusive. METHODS: C...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Alzheimers Res Ther |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BioMed Central
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7603780/ https://ncbi.nlm.nih.gov/pubmed/33129344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00708-0 |
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