SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks

Protecting replication fork integrity during DNA replication is essential for maintaining genome stability. Here, we report that SDE2, a PCNA-associated protein, plays a key role in maintaining active replication and counteracting replication stress by regulating the replication fork protection comp...

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Publicado en:Nat Commun
Autores principales: Rageul, Julie, Park, Jennifer J., Zeng, Ping Ping, Lee, Eun-A, Yang, Jihyeon, Hwang, Sunyoung, Lo, Natalie, Weinheimer, Alexandra S., Schärer, Orlando D., Yeo, Jung-Eun, Kim, Hyungjin
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7603486/
https://ncbi.nlm.nih.gov/pubmed/33127907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19162-5
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