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Conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks

Multiple pathways counteract DNA replication stress to prevent genomic instability and tumorigenesis. The recently identified human SDE2 is a genome surveillance protein regulated by PCNA, a DNA clamp and processivity factor at replication forks. Here, we show that SDE2 cleavage after its ubiquitin-...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Rageul, Julie, Park, Jennifer J, Jo, Ukhyun, Weinheimer, Alexandra S, Vu, Tri T M, Kim, Hyungjin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486553/
https://ncbi.nlm.nih.gov/pubmed/30698750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz054
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