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Brain-Targeted Delivery of Pre-miR-29b Using Lactoferrin-Stearic Acid-Modified-Chitosan/Polyethyleneimine Polyplexes

The efficacy of brain therapeutics is largely hampered by the presence of the blood–brain barrier (BBB), mainly due to the failure of most (bio) pharmaceuticals to cross it. Accordingly, this study aims to develop nanocarriers for targeted delivery of recombinant precursor microRNA (pre-miR-29b), fo...

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Detalhes bibliográficos
Publicado no:Pharmaceuticals (Basel)
Main Authors: Pereira, Patrícia, Barreira, Maria, Cruz, Carla, Tomás, Joana, Luís, Ângelo, Pedro, Augusto Q., Queiroz, João A., Sousa, Fani
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7602608/
https://ncbi.nlm.nih.gov/pubmed/33076502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph13100314
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