Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers

SIMPLE SUMMARY: Triple-negative breast cancer (TNBC) is associated with the high rates of relapse and metastasis and poor survival. YB-1 is overexpressed in TNBC tumor tissues. In the present study, we demonstrated that S102 phosphorylation of YB-1 in TNBC cell lines depend on the mutation status of...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Tiwari, Aadhya, Iida, Mari, Kosnopfel, Corinna, Abbariki, Mahyar, Menegakis, Apostolos, Fehrenbacher, Birgit, Maier, Julia, Schaller, Martin, Brucker, Sara Y., Wheeler, Deric L., Harari, Paul M., Rothbauer, Ulrich, Schittek, Birgit, Zips, Daniel, Toulany, Mahmoud
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7601769/
https://ncbi.nlm.nih.gov/pubmed/33003386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102795
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