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Epac1 Is Crucial for Maintenance of Endothelial Barrier Function through A Mechanism Partly Independent of Rac1

Epac1 (exchange protein activated by cAMP) stabilizes the endothelial barrier, but detailed studies are limited by the side effects of pharmacological Epac1 modulators and transient transfections. Here, we compare the key properties of barriers between endothelial cells derived from wild-type (WT) a...

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Publicado en:Cells
Main Authors: García-Ponce, Alexander, Schuster, Katharina, Døskeland, Stein-Ove, Reed, Rolf K., Curry, Fitz-Roy E., Waschke, Jens, Radeva, Mariya Y.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7601253/
https://ncbi.nlm.nih.gov/pubmed/32992982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102170
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