Rac1 Is Crucial for Hair Follicle Integrity but Is Not Essential for Maintenance of the Epidermis

Rac1 is a small GTPase that regulates the actin cytoskeleton but also other cellular processes. To investigate the function of Rac1 in skin, we generated mice with a keratinocyte-restricted deletion of the rac1 gene. Rac1-deficient mice lost nearly all of their hair within a few weeks after birth. T...

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Main Authors: Chrostek, Anna, Wu, Xunwei, Quondamatteo, Fabio, Hu, Rong, Sanecka, Anna, Niemann, Catherin, Langbein, Lutz, Haase, Ingo, Brakebusch, Cord
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592871/
https://ncbi.nlm.nih.gov/pubmed/16943436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00075-06
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