Blockage of Store-Operated Ca(2+) Influx by Synta66 is Mediated by Direct Inhibition of the Ca(2+) Selective Orai1 Pore

SIMPLE SUMMARY: Store-operated calcium channels constituted from the proteins Orai and STIM are important targets for development of new drugs, especially for the treatment of auto-immune diseases. Also, interference with channel function is linked to reduced cancer cell progression, making these ch...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Waldherr, Linda, Tiffner, Adela, Mishra, Deepti, Sallinger, Matthias, Schober, Romana, Frischauf, Irene, Schmidt, Tony, Handl, Verena, Sagmeister, Peter, Köckinger, Manuel, Derler, Isabella, Üçal, Muammer, Bonhenry, Daniel, Patz, Silke, Schindl, Rainer
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600887/
https://ncbi.nlm.nih.gov/pubmed/33036292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102876
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