HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1

We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6’s ubiquitin E3 ligase activity. Here, we have reported HDAC6’s second potential E3 ligase substrate, a critical cell cycle checkpoint...

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Publicat a:Cells
Autors principals: Moses, Niko, Zhang, Mu, Wu, Jheng-Yu, Hu, Chen, Xiang, Shengyan, Geng, Xinran, Chen, Yue, Bai, Wenlong, Zhang, You-Wei, Bepler, Gerold, Zhang, Xiaohong Mary
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600810/
https://ncbi.nlm.nih.gov/pubmed/33020410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102237
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