Competitive sgRNA Screen Identifies p38 MAPK as a Druggable Target to Improve HSPC Engraftment

Previous gene therapy trials for X-linked chronic granulomatous disease (X-CGD) lacked long-term engraftment of corrected hematopoietic stem and progenitor cells (HSPCs). Chronic inflammation and high levels of interleukin-1 beta (IL1B) might have caused aberrant cell cycling in X-CGD HSPCs with a c...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Klatt, Denise, Ha, Teng-Cheong, Schinke, Maximilian, Selich, Anton, Lieske, Anna, Dahlke, Julia, Morgan, Michael, Maetzig, Tobias, Schambach, Axel
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600420/
https://ncbi.nlm.nih.gov/pubmed/33003308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102194
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