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cPLA(2)α Enzyme Inhibition Attenuates Inflammation and Keratinocyte Proliferation

As a regulator of cellular inflammation and proliferation, cytosolic phospholipase A(2) α (cPLA(2)α) is a promising therapeutic target for psoriasis; indeed, the cPLA(2)α inhibitor AVX001 has shown efficacy against plaque psoriasis in a phase I/IIa clinical trial. To improve our understanding of the...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Ashcroft, Felicity J., Mahammad, Nur, Midtun Flatekvål, Helene, J. Feuerherm, Astrid, Johansen, Berit
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600040/
https://ncbi.nlm.nih.gov/pubmed/33023184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10101402
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