Complete Loss of EPCAM Immunoexpression Identifies EPCAM Deletion Carriers in MSH2-Negative Colorectal Neoplasia

SIMPLE SUMMARY: Colorectal carcinomas from patients with Lynch syndrome (LS) due to EPCAM deletions show loss of MSH2 expression. The aim of our study was to evaluate the usefulness of EPCAM expression in identifying carriers of EPCAM deletion among patients with MSH2-negative lesions. MSH2 and EPCA...

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Udgivet i:Cancers (Basel)
Main Authors: Cuatrecasas, Míriam, Gorostiaga, Iñigo, Riera, Cristina, Saperas, Esteban, Llort, Gemma, Costa, Irmgard, Matias-Guiu, Xavier, Carrato, Cristina, Navarro, Matilde, Pineda, Marta, Dueñas, Núria, Brunet, Joan, Marco, Vicente, Trias, Isabel, Busteros, José Ignacio, Mateu, Gemma, Balaguer, Francesc, Fernández-Figueras, María-Teresa, Esteller, Manel, Musulén, Eva
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7599495/
https://ncbi.nlm.nih.gov/pubmed/33003511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102803
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