Cytoplasmic MSH2 Related to Genomic Deletions in the MSH2/EPCAM Genes in Colorectal Cancer Patients With Suspected Lynch Syndrome

BACKGROUND: A large proportion of patients with Lynch syndrome (LS) have MSH2 abnormalities, but genotype-phenotype studies of MSH2 mutations in LS are still lacking. The aim of this study was to comprehensively analyze the clinicopathological characteristics and molecular basis of colorectal cancer...

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Udgivet i:Front Oncol
Main Authors: Dong, Lin, Zou, Shuangmei, Jin, Xianglan, Lu, Haizhen, Zhang, Ye, Guo, Lei, Cai, Jianqiang, Ying, Jianming
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162378/
https://ncbi.nlm.nih.gov/pubmed/34055602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.627460
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