Recombinant MDA-7/IL-24 suppresses prostate cancer bone metastasis through down regulation of the Akt/Mcl-1 pathway

Prostate cancer (PC) is a principal cause of cancer-associated morbidity in men. Although 5-year survival of patients with localized PC approaches 100 percent, survival decreases precipitously after metastasis. Bone is the preferred site for disseminated PC cell colonization, altering the equilibriu...

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Udgivet i:Mol Cancer Ther
Main Authors: Pradhan, Anjan K., Bhoopathi, Praveen, Talukdar, Sarmistha, Shen, Xue-Ning, Emdad, Luni, Das, Swadesh K., Sarkar, Devanand, Fisher, Paul B.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598934/
https://ncbi.nlm.nih.gov/pubmed/29934341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-1002
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