Mechanism of internalization of MDA-7/IL-24 protein and its cognate receptors following ligand-receptor docking

Melanoma differentiation associated gene-7 (mda-7/IL-24) is a member of the IL-10 family of cytokines, with ubiquitous direct and “bystander” tumor-selective killing properties. MDA-7/IL-24 protein binds distinct type II cytokine heterodimeric receptor complexes, IL-20R1/IL-20R2, IL-22R1/IL-20R1 and...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Pradhan, Anjan K., Bhoopathi, Praveen, Talukdar, Sarmistha, Das, Swadesh K., Emdad, Luni, Sarkar, Devanand, Ivanov, Andrei I., Fisher, Paul B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707942/
https://ncbi.nlm.nih.gov/pubmed/31489119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27150
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