EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin

Epstein-Barr virus–induced gene 3 (EBI3) is a subunit common to IL-27, IL-35, and IL-39. Here, we explore an intracellular role of EBI3 that is independent of its function in cytokines. EBI3-deficient naive CD4(+) T cells had reduced IFN-γ production and failed to induce T cell–dependent colitis in...

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Pubblicato in:J Clin Invest
Autori principali: Mizoguchi, Izuru, Ohashi, Mio, Hasegawa, Hideaki, Chiba, Yukino, Orii, Naoko, Inoue, Shinya, Kawana, Chiaki, Xu, Mingli, Sudo, Katsuko, Fujita, Koji, Kuroda, Masahiko, Hashimoto, Shin-ichi, Matsushima, Kouji, Yoshimoto, Takayuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598073/
https://ncbi.nlm.nih.gov/pubmed/32809973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122732
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